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世界首例基因编辑猪肝移植人体成功 为器官短缺提供突破性方案

中科院院士窦科峰团队利用经6处基因编辑的猪肝脏,移植至一名脑死亡但体征稳定的患者体内,同时保留其自身肝脏以模拟肝衰竭支持治疗。移植后10天观察期内,猪肝在人体内正常分泌胆汁、血供稳定,未出现超急性排斥反应及猪内源性逆转录病毒传播。该成果获《自然》杂志认定为异种器官移植领域里程碑。

研究严格遵循学术及伦理审查程序,移植对象为家属同意参与的脑死亡患者,实验在伦理委员会监督下完成,10天后因家属意愿终止。此前,基因编辑猪心脏、肾脏移植人体的案例已逐步推进,但肝脏移植因血液供应复杂性更具挑战。

牛津大学教授彼得·弗兰德称该技术“非常精妙”,为临床应用奠定基础。通过基因编辑技术减少免疫排斥风险,异种移植或成解决全球器官短缺的关键路径。

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Nature

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世界首例基因编辑猪肝移植人体成功 为器官短缺提供突破性方案

中科院院士窦科峰团队利用经6处基因编辑的猪肝脏,移植至一名脑死亡但体征稳定的患者体内,同时保留其自身肝脏以模拟肝衰竭支持治疗。移植后10天观察期内,猪肝在人体内正常分泌胆汁、血供稳定,未出现超急性排斥反应及猪内源性逆转录病毒传播。该成果获《自然》杂志认定为异种器官移植领域里程碑。

研究严格遵循学术及伦理审查程序,移植对象为家属同意参与的脑死亡患者,实验在伦理委员会监督下完成,10天后因家属意愿终止。此前,基因编辑猪心脏、肾脏移植人体的案例已逐步推进,但肝脏移植因血液供应复杂性更具挑战。

牛津大学教授彼得·弗兰德称该技术“非常精妙”,为临床应用奠定基础。通过基因编辑技术减少免疫排斥风险,异种移植或成解决全球器官短缺的关键路径。

新华社
Nature

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How Does Bitcoin Work?

Bitcoin is built on a distributed digital record called a blockchain. As the name implies, blockchain is a linked body of data, made up of units called blocks that contain information about each and every transaction, including date and time, total value, buyer and seller, and a unique identifying code for each exchange. Entries are strung together in chronological order, creating a digital chain of blocks. “Once a block is added to the blockchain, it becomes accessible to anyone who wishes to view it, acting as a public ledger of cryptocurrency transactions,” says Stacey Harris, consultant for Pelicoin, a network of cryptocurrency ATMs. Blockchain is decentralized, which means it’s not controlled by any one organization. “It’s like a Google Doc that anyone can work on,” says Buchi Okoro, CEO and co-founder of African cryptocurrency exchange Quidax. “Nobody owns it, but anyone who has a link can contribute to it. And as different people update it, your copy also gets updated.”

Spiking bond yields driving sharp losses in tech stocks

A spike in interest rates since the start of the year has accelerated a rotation out of high-growth technology stocks and into value stocks poised to benefit from a reopening of the economy. The Nasdaq has fallen more than 10% over the past month as the Dow has soared to record highs, with a spike in the 10-year US Treasury yield acting as the main catalyst. It recently surged to a cycle high of more than 1.60% after starting the year below 1%. But according to Jim Paulsen, the Leuthold Group's chief investment strategist, rising interest rates do not represent a long-term threat to the stock market. Paulsen expects the 10-year yield to cross 2% by the end of the year. A spike in interest rates and its impact on the stock market depends on the economic backdrop, according to Paulsen. Rising interest rates amid a strengthening economy "may prove no challenge at all for stocks," Paulsen said.

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