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Heparin = intrinsic • Warfarin= extrinsic

• INR measures extrinsic pathway
• aPTT measure intrinsic
• All coagulation factors are coming from the liver except factor 8 from the endothelium

• Factor 7 is the shortest half life and that’s why in liver disease the INR will be affected earlier than than aPTT

• Any problem with common pathway will result in prolonged both INR and aPTT



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Heparin = intrinsic • Warfarin= extrinsic

• INR measures extrinsic pathway
• aPTT measure intrinsic
• All coagulation factors are coming from the liver except factor 8 from the endothelium

• Factor 7 is the shortest half life and that’s why in liver disease the INR will be affected earlier than than aPTT

• Any problem with common pathway will result in prolonged both INR and aPTT

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